The following is a comprehensive list of former TCU baseball players who have reached the major leagues.

Louis Drucke 1909-1912 - New York Giants (1909-1912)
Ona Dodd 1912 - Pittsburgh Pirates (1912)
Jim Haislip 1913 - Philadelphia Phillies (1913)
Claude Cooper 1913-1917 - New York Giants (1913); Philadelphia Phillies (1916-1917)
Pete Donahue 1921-1932 - Cincinnati Reds (1921-1930); New York Giants (1930-1931); Cleveland Indians (1931); Boston Red Sox (1932)
A.S. Douglass 1921-1925 - Cincinnati Reds (1921,1925)
Boob Fowler 1923-1926 - Cincinnati Reds (1923-1925); Boston Red Sox (1926)
Leo Tankersley 1925 - Chicago White Sox (1925)
Bear Wolf 1927 - Cincinnati Reds (1927)
Tex Carleton 1932-1940 - Saint Louis Cardinals (1932-1934); Chicago Cubs (1935-1938); Brooklyn Dodgers (1940)
Slim Kinzy 1934 - Chicago White Sox (1934)
Dutch Meyer 1937-1946 - Chicago Cubs (1937); Detroit Tigers (1940-1942); Cleveland Indians (1945-1946)
Randy Jackson 1950-1959 - Chicago Cubs (1950-1955, 1959); Brooklyn Dodgers (1956-1957); Los Angeles Dodgers (1958); Cleveland Indians (1958-1959)
Jim Busby 1950-1962 - Chicago White Sox (1950-1952, 1955); Washington Senators (1952-1955); Cleveland Indians (1956-1957); Baltimore Orioles (1957-1958, 1960-1961); Boston Red Sox (1959-1960); Houston Colt .45's (1962)
Carl Warwick 1961-1966 - Los Angeles Dodgers (1961); Saint Louis Cardinals (1961-1962, 1964-1965); Houston Colt .45's (1962-1963); Baltimore Orioles (1965); Chicago Cubs (1966)
Tommy Gramly 1968 - Cleveland Indians (1968)
Chuck Machemehl 1971 - Cleveland Indians (1971)
Jeff Newman 1976-1984 - Oakland (1976-1982); Boston Red Sox (1983-1984)
Freddie Benavides 1991-1994 - Cincinnati Reds (1991-1992); Colorado Rockies (1993); Montreal Expos (1994)
Tim Mauser 1991-1995 - Philadelphia Phillies (1991,1993); San Diego Padres (1993-1995)
John Briscoe 1991-1996 - Oakland Athletics (1991-1996)
Chris Eddy 1995 - Oakland Athletics (1995)
Glenn Dishman 1995-1997 - San Diego Padres (1995-1996); Philadelphia Phillies (1996); Detroit Tigers (1997)
Jeff Zimmerman 1999-2001 - Texas Rangers (1999-2001)
Scott Atchison 2004-Present - Seattle Mariners (2004-06); San Francisco Giants (2007)
Lance Broadway 2007-Present - Chicago White Sox (2007-present)
Eugene Espineli 2008-Present - San Francisco Giants (2008-present)
German Duran 2008-Present - Texas Rangers (2008-present)