| Day | Date | Opponent | Location | TV | |
| Sat | 10/29/05 | Basketball Fan Fest | Petersen Events Center | | 4:00 p.m.
Gametracker |
| Sat | 11/05/05 | Slippery Rock (Exh.) | Petersen Events Center | | W, 100-42
Recap | Box Score | Photo Gallery |
| Sun | 11/13/05 | Indiana Univ. (PA) (Exh.) | Petersen Events Center | | W, 74-55
Recap | Box Score | Photo Gallery |
| Sat | 11/19/05 | Saint Peter's | Petersen Events Center | | W, 82-71
Recap | Box Score | Quotes | Notes | Photo Gallery | Gametracker |
| Wed | 11/23/05 | Robert Morris | Petersen Events Center | | W, 86-59
Recap | Box Score | Quotes | Notes | Photo Gallery | Gametracker |
| Sat | 11/26/05 | Maine | Petersen Events Center | | W, 62-49
Recap | Box Score | Quotes | Notes | Photo Gallery | Gametracker |
| Tue | 11/29/05 | St. Francis N.Y. | Petersen Events Center | | W, 79-58
Recap | Box Score | Quotes | Notes | Photo Gallery | Gametracker |
| Sun | 12/04/05 | Auburn | Petersen Events Center | | W, 78-41
Recap | Box Score | Quotes | Notes | Photo Gallery | Gametracker |
| Wed | 12/07/05 | at Duquesne | Pittsburgh, Pa./A.J. Palumbo Center | FSN | W, 71-60
Recap | Box Score | Quotes | Notes | Gametracker |
| Sat | 12/10/05 | Penn State | Petersen Events Center | FSN | W, 91-54
Recap | Box Score | Quotes | Notes | Gametracker |
| Sat | 12/17/05 | Vermont | Petersen Events Center | | W, 63-52
Recap | Box Score | Quotes | Notes | Photo Gallery | Gametracker |
| Wed | 12/21/05 | Coppin State | Petersen Events Center | | W, 77-51
Recap | Box Score | Quotes | Notes | Gametracker |
| Wed | 12/28/05 | at South Carolina | Columbia, S.C./Colonial Center | CSS-TV | W, 58-51
Recap | Box Score | Quotes | Notes | Gametracker |
| Sat | 12/31/05 | Wisconsin | Petersen Events Center | FSN | W, 73-64
Recap | Box Score | Quotes | Notes | Gametracker |
| Wed | 01/04/06 | Notre Dame | Petersen Events Center | FSN | W, 100-97 (2OT)
Recap | Box Score | Quotes | Notes | Photo Gallery | Gametracker |
| Thu | 01/12/06 | DePaul | Petersen Events Center | ESPN | W, 73-65
Recap | Box Score | Quotes | Notes | Gametracker |
| Sun | 01/15/06 | at Louisville | Louisville, Ky./Freedom Hall | WTAE-TV | W, 61-57
Recap | Box Score | Quotes | Notes | Photo Gallery | Gametracker |
| Wed | 01/18/06 | at Rutgers | Piscataway, N.J./Louis Brown Athletic Center | FSN | W, 76-68
Recap | Box Score | Quotes | Notes | Gametracker |
| Sat | 01/21/06 | at St. John's | New York, N.Y./Madison Square Garden | WTAE-TV | L, 50-55
Recap | Box Score | Quotes | Notes |
| Mon | 01/23/06 | Syracuse | Petersen Events Center | ESPN | W, 80-67
Recap | Box Score | Quotes | Notes | Photo Gallery | Gametracker |
| Sat | 01/28/06 | Marquette | Petersen Events Center | WTAE-TV | W, 77-71
Recap | Box Score | Quotes | Notes | Photo Gallery | Gametracker |
| Tue | 01/31/06 | at Connecticut | Storrs, Conn./Gampel Pavilion | FSN | L, 80-76
Recap | Box Score | Quotes | Notes |
| Sun | 02/05/06 | at Georgetown | Washington, D.C./MCI Center | FSN | L, 61-58
Recap | Box Score | Notes | Gametracker |
| Thu | 02/09/06 | West Virginia | Petersen Events Center | ESPN | W, 57-53
Recap | Box Score | Quotes | Notes | Photo Gallery | Gametracker |
| Sun | 02/12/06 | Cincinnati | Petersen Events Center | FSN | W, 89-69
Recap | Box Score | Quotes | Notes | Gametracker |
| Wed | 02/15/06 | at Providence | Providence, R.I./Dunkin' Donuts Center | FSN | W, 85-77
Recap | Box Score | Notes | Photo Gallery | Gametracker |
| Sat | 02/18/06 | at Marquette | Milwaukee, Wisc./Bradley Center | FSN | L, 84-82
Recap | Box Score | Quotes | Notes |
| Sat | 02/25/06 | Providence | Petersen Events Center | FSN | W, 81-68
Recap | Box Score | Quotes | Notes | Photo Gallery | Gametracker |
| Mon | 02/27/06 | at West Virginia | Morgantown, W.Va./WVU Coliseum | ESPN | L, 67-62
Recap | Box Score | Notes | Gametracker |
| Fri | 03/03/06 | Seton Hall | Petersen Events Center | FSN | L, 65-61
Recap | Box Score | Quotes | Notes | Photo Gallery | Gametracker |
| Wed | 03/08/06 | Louisville | New York, N.Y. (MSG) | ESPN | W, 61-56
Recap | Box Score | Notes |
| Thu | 03/09/06 | West Virginia | New York, N.Y. (MSG) | ESPN | W, 68-57
Recap | Box Score | Quotes | Notes | Photo Gallery | Gametracker |
| Fri | 03/10/06 | Villanova | New York, N.Y. (MSG) | ESPN | W, 68-54
Recap | Box Score | Quotes | Notes | Gametracker |
| Sat | 03/11/06 | Syracuse | New York, N.Y. (MSG) | ESPN | L, 65-61
Recap | Box Score | Quotes | Photo Gallery | Gametracker |
| Fri | 03/17/06 | Kent State | Auburn Hills, Mich. | CBS | W, 79-64
Recap | Box Score | Notes | Photo Gallery |
| Sun | 03/19/06 | Bradley | Auburn Hills, Mich. | CBS | L, 72-66
Recap | Box Score | Notes | Photo Gallery |
